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Bruxton Corp tac program
Tac Program, supplied by Bruxton Corp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tac+program/program+tac/pm39948358-352-4-6
Average 90 stars, based on 1 article reviews
tac program - by Bioz Stars, 2026-10
90/100 stars

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Article Title: Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor.
Article Snippet: Lamotrigine is an antiepileptic drug employed in the treatment of partial epilepsies.We studied its possible interactionwith channels other than its known therapeutic target, thevoltage-gated sodium channel, using the adult muscle nicotinic acetylcholine receptor as a model system.. At the single-channel level, lamotrigine caused a dose-dependent (a) diminution in mean open time, (b) increase in mean burst duration and (c) increase in the area of a new closedtime component.. A simple linear channel blocking mechanism accounts for these results.

Article Title: Unraveling anthelmintic targets and mechanisms of action of trans-cinnamaldehyde from cinnamon essential oil.
Article Snippet: Channels were analyzed using TAC program (Bruxton Corporation).

Article Title: Combined single-channel and macroscopic recording techniques to analyze gating mechanisms of the large conductance Ca2+ and voltage activated (BK) potassium channel.
Article Snippet: Ion channels are integral membrane proteins that regulate membrane potentials and signaling of cells in response to various stimuli.. The patch-clamp technique enables the study of single channels or a population of channels.. The macroscopic recording approaches are powerful in revealing population-averaged behaviors of channels both under basal conditions and in response to various stimuli, modulators and drugs.

Article Title: An S6 Mutation in BK Channels Reveals β1 Subunit Effects on Intrinsic and Voltage-dependent Gating
Article Snippet: Analysis was performed using TAC and TACFIT programs (Bruxton Corporations).

Article Title: A conserved arginine with non-conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors.
Article Snippet: Single-channel currents were digitised at 5- to 10-μs intervals, low-pass filtered at a cut-off frequency of 10 kHz using an Axopatch 200B patch-clamp amplifier (Molecular Devices, CA, USA) and analysed using the program TAC (Bruxton Corporation, Seattle, WA, USA) with the Gaussian digital filter at 9 kHz (final cut-off frequency 6.7 kHz).

Article Title: Design, Synthesis, and Functional Evaluation of a Novel Series of Phosphonate-Functionalized 1,2,3-Triazoles as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors.
Article Snippet: Single-channel currents were digitized at 5-10 μs intervals, lowpass filtered at a cut-off frequency of 10 kHz using an Axopatch 200B patch-clamp amplifier (Molecular Devices, CA, USA) and analyzed using the program TAC (Bruxton Corporation, Seattle, WA, USA) with the Gaussian digital filter at 9 kHz (Final cut-off frequency 6.7 kHz).

Article Title: Mechanism of Increased BK Channel Activation from a Channel Mutation that Causes Epilepsy
Article Snippet: Analysis was performed using TAC and TACFIT programs (Bruxton Corporation).




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